About Cutaneous Lymphoma

We exist to make sure each person gets the best care possible.

Brett Weiss

New York, NY

THIS IS AN ANXIOUS TIME, BUT WE ARE HERE TO HELP.
The Cutaneous Lymphoma Foundation's CEO, Susan Thornton talks about what it is like to be diagnosed with cutaneous lymphoma and how the Foundation helps through its mission of promoting awareness and education, advancing patient care, and facilitating research.

Presenter
Susan Thornton, Cutaneous Lymphoma Foundation CEO

WHAT IS CUTANEOUS LYMPHOMA?

Cutaneous lymphomas are a distinct subset of non-Hodgkin’s lymphoma. They are cancers of lymphocytes (white blood cells) that primarily involve the skin. Classification is based on lymphocyte type: B-lymphocytes (B-cell) or T-lymphocytes (T-cell).

CUTANEOUS T-CELL LYMPHOMA (CTCL)

Cutaneous T-cell lymphoma (CTCL) is the most common type of cutaneous lymphoma that typically presents with red, scaly patches or thickened plaques of skin that often mimic eczema or chronic dermatitis. Progression from limited skin involvement is variable and may be accompanied by tumor formation, ulceration, and exfoliation, complicated by itching and infections. Advanced stages are defined by involvement of lymph nodes, peripheral blood, and internal organs. Most CTCLs typically fall into the category of indolent (i.e. chronic) lymphomas – treatable, but not curable and usually not life-threatening.

CUTANEOUS B-CELL LYMPHOMAS (CBCL)

Cutaneous B-cell lymphomas (CBCL) are a less common version of cutaneous lymphomas, making up about 20-25% of all cutaneous lymphomas.   CBCLs are B-cell non-Hodgkin’s lymphomas which originate in skin-based B-cells.  Systemic or nodal B-cell lymphomas can secondarily involve the skin and when a skin biopsy shows B-cell lymphoma it is very important to make sure that the skin is the only organ involved and that  this is not a systemic lymphoma presenting in the skin.  The most common forms of CBCL are slow growing or indolent variations and respond well to mild treatments.

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WHAT TYPE OF CUTANEOUS LYMPHOMA DO I HAVE?

Cutaneous T-cell Lymphoma

CTCL is the acronym for cutaneous T-cell lymphoma, a general term for several types of lymphomas of the skin that derive from T-cells. We've provided an overview of the disease, treatment and prognosis.

Mycosis Fungoides

Mycosis fungoides is the most common form of cutaneous T-cell lymphoma (CTCL). Because of that, the terms are often used interchangeably, and sometimes imprecisely. Mycosis fungoides is just one type of CTCL. Learn more about how it is diagnosed, treated and its prognosis.

SÉZARY SYNDROME

The two most common types of cutaneous T-cell lymphomas are mycosis fungoides, which is often indolent, and an advanced and leukemic form of mycosis fungoides called Sézary syndrome. Learn how Sézary syndrome is diagnosed, its treatments and prognosis.

Primary Cutaneous B-cell Lymphoma

Primary cutaneous B-cell lymphomas (CBCLs) are a cutaneous lymphoma that affects B-cells in the skin. Learn more about its diagnosis, variants, treatment options and prognosis.

Lymphomatoid Papulosis

Lymphomatoid Papulosis (LyP) is a disease of the immune system that manifests with self-healing small bumps and spots on the skin that come and go. Learn more about how it is diagnosed, treated and its prognosis.

PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA

Primary cutaneous T-cell lymphomas (CTCL) are part of a group of rare non-Hodgkin lymphomas that arise from the T-cell type lymphocytes. Learn more about how it is diagnosed, the variants, treatments and prognosis.
THERE IS HOPE

Many effective treatment options exist for cutaneous lymphoma.  You and your health care team will determine the best course of treatment.

The goal of treatment for cutaneous lymphoma is to clear up all patches, plaques, or tumors; to reduce the number of T-lymphocytes in the blood (for Sézary syndrome); and to relieve symptoms such as pain, itching, burning, and redness.  Additionally, patients tend to handle treatments better when they maintain a healthy diet and exercise regimen and report any new symptoms or changes to their physicians during treatment.

Learn More About Treatment Options

For illustrative purposes only.
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Related Research

Skin-Directed Tactics Optimal for Early Cutaneous Lymphoma

For patients with early-stage cutaneous lymphoma, skin-directed treatments, such as topical steroids and phototherapy, can slow or halt progression, but patients are also being treated with systemic therapies, according to the first-of-its kind research on this rare malignancy.

Modernizing Immunotherapy for Cutaneous T-cell Lymphoma

For decades, immunotherapy has been a cornerstone of systemic therapy for cutaneous T cell lymphoma (CTCL). It is therefore not surprising that modern immune-therapies, which target anti-tumor immunity in more sophisticated ways, have the potential to greatly improve our treatments for CTCL. 

Epigenetics & Biology of Cutaneous T-cell Lymphomas

These are exciting times in cutaneous T-cell lymphoma (CTCL) research. The hard work of laboratory and clinical investigators worldwide is starting to bear fruit, and a number of basic discoveries in the genetic and epigenetic foundations of CTCL are now being translated into novel therapies, with great impact for patients.