Brief Summary:

The primary endpoint is to determine if ECP induces a decrease in % of tumor cells after treatment. 15 patients with Sezary Syndrome will receive ECP weekly x4, then bi-weekly for 5 months. Each patient will donate 5 samples to determine immune responses in peripheral blood. Additional clinical assessments will be a modified skin weighted assessment and flow cytometry at baseline and months 3 and 6. A CT scan will be obtained at baseline and only repeated if pathology is present at baseline. The tumor microenvironment will be studied by comparing transcriptomics of the blood samples before, 1 day after first ECP treatment, cycle 1, 1, 3 and 6 months after ECP treatment by scRNAseq (5 samples total per patient ).

Website: https://clinicaltrials.gov/ct2/show/NCT05157581?term=Photopheresis+%2B+Sezary+Syndrome%3A+Evaluating+Tumor-specific+Immunity&draw=2&rank=1

Sponsors and Collaborators

Oleg E Akilov, MD, PhD

Mallinckrodt

Investigators

Principal Investigator: Oleg E Akilov, MD, PhD University of Pittsburgh

Contacts and Locations

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05157581