Types of Treatment

Expert Presenter

Alain H. Rook, MD, Professor of Dermatology, University of Pennsylvania, Perelman School of Medicine

CUTANEOUS T- CELL LYMPHOMA TREATMENT: An Overview

A wide variety of treatments exist and learning what type may be appropriate for you can be challenging. In this video series, Dr. Rook presents an overview and explanation of treatments and how treatment plans are determined.

Part 1
What do I need to know about how treatment is determined?

Dr. Rook provides an explanation of how cutaneous lymphoma affects the skin and how that determines the type of treatment that is appropriate. Treatments discussed in this video are appropriate for individuals who have limited patches and/or plaques on their skin.

Treatments

  • Potent Topical Steroids
  • Nitrogen Mustard 
  • Carmustine 
  • Narrow band UVB (ultraviolet light therapy)
  • PUVA (Psoralin & UVA)
  • Other topicals (Retinoids): Imiquiod cream, Targretin gel and Tazorac (Tazarotene) cream or gel
CUTANEOUS T- CELL LYMPHOMA TREATMENT: EARLY STAGE

EXPERT PRESENTER

Alain H. Rook, MD, Professor of Dermatology, University of Pennsylvania, Perelman School of Medicine

Part 2
What are treatments for more advanced cutaneous lymphoma?

In this video Dr. Rook looks at systemic therapies that are taken by mouth (orally) or through injection as well as treatments for tumors. Systemic therapies may be used for individuals with more than 10% of their skin affected by patches/plaques. Dr. Rook also discusses when bone marrow (stem cell) transplants may be an appropriate treatment option.

Treatments

  • Interferon alpha
  • Bexarotene (Targretin - oral)
  • Radiation - Total Skin Electron Beam (TSEB)
  • Chemotherapy
  • HDAC Inhibitors
  • Bone Marrow (stem cell) Transplant
CUTANEOUS T- CELL LYMPHOMA TREATMENT: ADVANCED STAGE

EXPERT PRESENTER

Alain H. Rook, MD, Professor of Dermatology, University of Pennsylvania, Perelman School of Medicine

Part 3
What are treatments for Sézary syndrome?

In this final video, Dr. Rook focuses on treatments for erythrderma (redness of the skin) related to Sézary syndrome. Targeted tumor therapy is also explored further as is bone marrow transplants.

Treatments

  • Photopheresis 
  • Interfern gamma
  • Imiquimod cream
  • PUVA with Psoralen
  • Total Skin Electron Beam (TSEB) therapy
  • Targeted tumor therapy: Campath (Alemtuzumab) and Ontak (Denileukin Diftitox)
  • HDAC Inhibitors: Vorinostat and Romidepsin
  • Allogeneic (bone) Marrow Transplant
  • Brentuximab Vedotin
  • Chemotherapy
CUTANEOUS T- CELL LYMPHOMA TREATMENT: SEZARY SYNDROME

EXPERT PRESENTER

Alain H. Rook, MD, Professor of Dermatology, University of Pennsylvania, Perelman School of Medicine

Learn More

Radiation Therapy - Local and TSEB

Radiation therapy is the use of focused, high energy beams of X-rays, photons, or electrons to treat cancer. Today, radiation therapy is used to treat individual CTCL lesions (local or spot treatment) or the entire skin surface (total skin). 

Phototherapy - UVB and PUVA

Ultraviolet (UV) light therapy, or phototherapy, is one of the most widely used skin-directed therapies for cutaneous T-cell lymphoma (CTCL). UVA and UVB are wavelengths of light found in natural sunlight, and are used for phototherapy.

Skin-Directed Therapies

Individuals with disease limited to the skin (stages I and II) can often achieve a good response with one of the readily available skin-directed therapies. Learn more about skin-directed therapies.
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